In the past 20 years, these drugs have been widely used in a variety of skin treatments. Currently, vitamin A acid drugs can be divided into three generations, first generation is non-aromatic vitamin A acid; second generation is single aromatic vitamin A acid; third generation is multi- aromatic vitamin A acid. Wherein the oral medication for the treatment of acne is mainly the first generation vitamin A acid, the other vitamin A acid are used ascosmetic raw material.
The pathway of first generation vitamin A acid curing acne are mainly have four aspects:` Vitamin A acid can extend basal cell maturation process, and reduce the number of sebaceous glands, sebum synthesis is also reduced, thereby reducing sebum secretion. a Vitamin A acid by regulating the division and update of epidermal cells, inhibit epidermal keratinocytes, so that play the role of opening up pore blockage. bVitamin A acid can change the lipid composition within sebaceous gland, inhibit the acnes propionibacterium which depends on the lipid environment to grow, so as to achieve the purpose of anti-inflammatory. c significantly reduce the non-specific inflammation. In summary, vitamin A acid drugs can act on all aspects of acne treatment, maximize to reach the purpose of clearing acne. But according to tretinoin manufacturer, the vitamin A acid drugs have teratogenic effect, can cause elevated blood lipids, thus banned in pregnant women or those women who plan to become pregnant within a year. Severe high cholesterol and abnormal liver function patients should also avoid using it. Meanwhile, during the treatment will have significantly dry mouth, dry eyes and dry skin feelings, in the succedaneum of vitamin A acid drugs, isotretinoin is a representative.
From the pharmacological perspective, the main reason to cause acne is mainly in four aspects: ` hair follicle infundibulum epithelial cells keratinized; a Propionibacterium acnes mass propagation; b sebum large secretion; c patient’s inflammatory response. Because of isotretinoin has suppression and treatment effect on these four aspects, so the isotretinoin can radically treat acne. In these oral drugs which used in treating acne, only isotretinoin can reduce the recurrence of acne.
Using those drugs in treating acne should be noted that because isotretinoin belongs vitamin A acid drugs, so it should avoid using with vitamin A in order to avoid body’s excessive vitamin A, cause vitamin A excessive symptoms. In addition, the process of taking isotretinoin should avoid using tetracycline antibiotic, so as not to cause intracranial pressure increased, resulting in the so-called pseudotumor cerebri phenomenon. People with liver and kidney dysfunction should not take it. Most importantly, because all the vitamin A acid drugs can affect fetal development, so that after taking this drug needs contraception, but the time of different tretinonin discharged from the body is different, thus the requiring contraception period is not the same. Isotretinoin requires the shortest contraceptive time in all the oral Vitamin A acid drugs, after stopping meditation only need three months contraceptive time. While others tretinoin, such as viaminate requires contracepting six months.
The incidence of acne has a variety of factors, of which the bacterial infection has played a role in disease occurrence and development. For example, the most isolated from acne vulgaris patients papules, pustules and acne is anaerobic bacteria, including Propionibacterium acnes and Propionibacterium acnes particles; aerobic bacteria including Staphylococcus aureus, middletype Staphylococcus aureus and Staphylococcus epidermidis, Propionibacterium acnes which is most common. In the acne, the Propionibacterium acnes and Staphylococcus epidermidis increased significantly, while in pustules, Staphylococcus aureus is the most. where to buy Tretinoin